USANA Information and NUTRITION Links

This page contains a set of useful links to help understand oxidative stress, USANA products, becoming a USANA Distributor, and successfully running your own business.

OXIDATIVE STRESS

A great deal of information is already nicely organized by the Oxidative Stress and Aging. In 1999, the Oxidative Stress and Aging (O2SA) Association was established to address the clinical aspects of oxidative stress and how it relates to longevity medicine. The O2SA Association is a not-for-profit organization and is governed by its bylaws and has an elected group of officers. Their list of links is at: http://www.o2sa.org/O2SAHomepage/OSandAging.htm

Here's a nice page (from the University of Wisconson's "Why Files,") that describes the cell furnace, the "mitochondria" which produce reactive by-products. This page suggests that limiting your intake of calories will create fewer actions in the mitochondria, thereby creating fewer disease producing free radicals. It also says that a panel of aging experts was asked if they took anti-oxidants, and all did so. Sponsored by the National Sanitation Foundation http://whyfiles.org/057aging/radical2.html

Another page from the Why Files, where the use of anti-oxidants is extending the lifespan of lab organisms. http://whyfiles.org/057aging/radical.html

This is Laz Bannock's page has a nice links to supplements, and has a good set of presentations and descriptions of the actions of oxidative stress. http://www.humannutrition.com

Here is a good set of "Health Information Resources:" http://www.usana.com/USSUBPAGE_36271.html

TAKING NUTRITIONAL SUPPLEMENTS

In 2002 the Journal of the American Medical Association published some remarkable findings about nutrition and illness.

Here is the abstract of an article about the associaton of taking a broad spectrum anti-oxidant - for prevention of Alzheimers disease:

Dietary Intake of Antioxidants and Risk of Alzheimer Disease
Marianne J. Engelhart, MD,MSc; Mirjam I. Geerlings, PhD; Annemieke Ruitenberg, MD,PhD; John C. van Swieten, MD,PhD; Albert Hofman, MD,PhD; Jacqueline C. M. Witteman, PhD; Monique M. B. Breteler, MD,PhD


JAMA. 2002;287:3223-3229.

Context Laboratory findings have suggested that oxidative stress may contribute to the pathogenesis of Alzheimer disease. Therefore, the risk of Alzheimer disease might be reduced by intake of antioxidants that counteract the detrimental effects of oxidative stress.

Objective To determine whether dietary intake of antioxidants is related to risk of Alzheimer disease.

Design and Setting The Rotterdam Study, a population-based, prospective cohort study conducted in the Netherlands.

Participants A total of 5395 participants who, at baseline (1990-1993), were aged at least 55 years, free of dementia, and noninstitutionalized and had reliable dietary assessment. Participants were reexamined in 1993-1994 and 1997-1999 and were continuously monitored for incident dementia.

Main Outcome Measures Incidence of Alzheimer disease, based on Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition (DSM-III-R) criteria and National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer Disease and Related Disorders Association (NINCDS-ADRDA) criteria, associated with dietary intake of beta carotene, flavonoids, vitamin C, and vitamin E.

Results After a mean follow-up of 6 years, 197 participants developed dementia, of whom 146 had Alzheimer disease. When adjustments were made for age, sex, baseline Mini-Mental State Examination score, alcohol intake, education, smoking habits, pack-years of smoking, body mass index, total energy intake, presence of carotid plaques, and use of antioxidative supplements, high intake of vitamin C and vitamin E was associated with lower risk of Alzheimer disease (rate ratios [RRs] per 1-SD increase in intake were 0.82 [95% confidence interval {CI}, 0.68-0.99] and 0.82 [95% CI, 0.66-1.00], respectively). Among current smokers, this relationship was most pronounced (RRs, 0.65 [95% CI, 0.37-1.14] and 0.58 [95% CI, 0.30-1.12], respectively) and also was present for intake of beta carotene (RR, 0.49 [95% CI, 0.27-0.92]) and flavonoids (RR, 0.54 [95% CI, 0.31-0.96]). The associations did not vary by education or apolipoprotein E genotype.

Conclusion High dietary intake of vitamin C and vitamin E may lower the risk of Alzheimer disease.


Author Affiliations: Department of Epidemiology and Biostatistics (Drs Engelhart, Geerlings, Ruitenberg, Hofman, Witteman, and Breteler), and Department of Neurology (Drs Ruitenberg and van Swieten), Erasmus Medical Center, Rotterdam, the Netherlands.

Additionally, the whole idea of taking a daily supplement was advocated by the Journal of the American Medical Association in 2002. The following article was taken from this site.

Journal of The American Medical Association Announces Recommendation that All Adults Should Take Vitamins

July 2002 -- In a landmark article published June 19, 2002, The Journal of The American Medical Association (JAMA) announced that all adultsshould take vitamin supplements to help prevent chronic diseases.

"Suboptimal folic acid levels, along with suboptimal levels of vitamins B6 and B12, are a risk factor for cardiovascular disease, neural tube defects, and colon and breast cancer; low levels of vitamin D contribute to osteopenia and fractures; and low levels of the antioxidant vitamins (vitamins A,E, and C) may increase risk for several chronic diseases. Most people do not consume an optimal amount of all vitamins by diet alone ... it appears prudent for all adults to take vitamin supplements," states the article by Robert H. Fletcher, MD, MSc and Kathleen M. Fairfield, MD, DrPH, both affiliated with Harvard Medical School.

Myths and facts about supplements: Provided by the Dietary Supplement Information Bureau, a non-profit watchdog of the health supplement industry - http://www.supplementinfo.org/industry/myths.htm There is also a lot of good information about nutrients and their effects here: http://www.supplementinfo.org/

COMPARING NUTRITIONAL SUPPLEMENTS

First of all, you should know that the FDA considers nutritional supplements food. They do not consider them to be drugs. The standards for potency, uniformity (consistency from dose to dose,) disintegration, and dissolution are not applied to these products. Shockingly, the FDA came out with a proposal recently to begin discussion on the regulation of supplements. "The proposal, announced March 7, would implement new, industry-wide standards in the manufacturing, packaging and holding of supplements, and ensure that they are labeled accurately and do not contain impurities or other contaminants." For the first time, the FDA is suggesting that supplements be tested to determine that they are what they say they are, and that they are produced according to the pharmaceutical Good Manufacturing Practices (GMP). USANA has been doing this (and testing for potency, uniformity, disintegration, and dissolution) since its inception in 1992. See if your nutritional supplement does this. You may not be getting what is on the label, or you may be getting something not on the label as a contaminant. Many manufacturers are simply not set up to test either their raw ingredients or what they produce.

When you compare supplements, look for the information on the label that differentiates your supplement, so that you can get the best product your body can have. When you shop for food, do you buy something that doesn't meet your quality standards, just because it's sale priced? Treat your supplements the same way. Look for proof that the products are top quality. Look for proof that they are tested for purity. Look for proof that the product will be able to break down as you digest it and be used by your body. The USP (US Pharmacopia) produces standards for potency, purity, uniformity, disintegration and dissolution (where applicable). Check to see whether the products are manufactured according to phamaceutical Good Manufacturing Practices (GMPs) federally mandated quality assurance guidelines established for the pharmaceutical industry. Look for products in the Phsician's Desk Reference (PDR.) Make sure that your supplement meets these standards. USANA does.

NUTRITIONAL SUPPLEMENTS AND WOMEN'S HEALTH

Dr. Christiane Northrup, MD (ob/gyn) is a practicing physician in Maine. Dr. Northrup is also the author of the New York Times best-selling book, Women’s Bodies, Women’s Wisdom (Bantam, revised 1998), which was #1 on Amazon.com in 1999, has been translated into eleven languages, and has sold over 1.2 million copies. Her work has been featured on the Oprah Winfrey Show, The View, NBC Nightly News with Tom Brokaw, Good Morning America, and the Today Show. She has also appeared on Donny & Marie. Her newest New York Times best-selling book, The Wisdom of Menopause: Creating Physical and Emotional Health and Healing During the Change (Bantam, 2001), #1 on Amazon.com in 2001 and 2002, explores the gifts and challenges of this midlife turning point, during which we have greater potential to create the foundation for a happier and healthier life than ever before. She is also at work on a book that will explore how the mother–daughter bond sets the stage for a woman’s health throughout the lifecycle. For information on women's health and nutrition, her website offers some strong information.

NUTRITIONAL SUPPLEMENTS - RELATIONSHIPS TO DISEASES

Cancer

There is substantial disagreement about the causes of cancer. One of the points of agreement is that cancer is an uncontrolled reproduction of cells. There is some level of agreement that the genetic activity causing cancers of many types can be linked to a specific gene, which causes the cell to have orderly and controlled replication. That gene is called p53. Harvard University Professor and PH.D. J. Kimball has a fantastic set of biology web pages, one of which goes into some depth on p53. p53 is an anti-oncogene, named as such for their reversal (in cell culture) the action of known oncogenes.

Damage to p53 and other DNA mutations may be caused through oxidative stress. Bruce N. Ames, Professor of Biochemistry and Molecular Biology and Director of the National Institute of Environmental Health Sciences Center at UC Berkley suggests clearly that oxidative stress directly relates to mutation at the cellular level. This widely held belief is consistant with the idea that supplying a sufficient level of nutrient anti-oxidants may quench free radicals, thereby reducing the chance of mutation, and subsequent diseases that result from mutation.

Another good source for nutritional information is the National Cancer Institute. The NCI has pages describing nutritional studies related to cancer, but also describe certain supplements in relation to other disorders (heart disease, etc.) Here is an excellent link on the coenzyme Q10 (also known as Co Q10, Q10, vitamin Q10, ubiquinone, and ubidecarenone - a benzoquinone compound synthesized naturally by the human body - which is included in the USANA Essentials antioxidant formulation): http://www.cancer.gov/cancerinfo/pdq/cam/coenzymeQ10

Co Q10 is available from USANA as the product "CoQuinone 30". CoQ10 not only facilitates in the production of energy at the cellular level, but it also (theoretically) cleans up free radicals produced in the process.1 As an antioxidant, it rivals vitamin E and C.2,3 In addition, CoQ10 helps to regenerate and recycle vitamin E and works in concert with other anti-oxidants to protect against the damaging effects of free radicals.1,4-5

USANA Essentials are not formulated as a nutritional supplement to treat disease, but they are designed to strengthen many of the body's natural defense mechanisms. The belief that "the body's multiple defence mechanisms work synergistically to combat disease," is widely accepted among health care professionals.

This section is incomplete. You can find a series of links regarding nutrition and specific conditions here.

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REFERENCES:

1 These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

2 Alleva R. et al., Mol Aspects Med. 1997; 81 Suppl:S1-5-12.

3 Kontush A. et al., Biochim Biophys Acta, 1995; 1258:177-87.

4 Littaru GP, Battino M, Folkers K, in Cardenas E and Packer L (eds) Handbook of Antioxidant. Marcel Dekker: New Yourk. 1966 PP 203-239.

5. Kagan VE, Hohl H, Quinn PJ, in Cardenas E and Packer L (eds) Handbook of Antioxidant. Marcel Dekker: New Yourk. 1966 PP 157-201.